Melanotan 2 Peptide 121062-08-6 Epidermal Growth Factor Skin
We can supply MT II 10 mg/vial.
Molecular formula: C50H69N15O9
Molar Mass: 1024.180
CAS number: 121062-08-6
Melanotan 2 Structural Name: Ac-cyclo[Nle4, Asp5, D-Phe7, Lys10]α-MSH4-10-NH2
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The Development of Melanotan 2
The initial creation of the synthetic Melanotan 2 peptide can be
credited to the University of Arizona. During the course of
research aimed at developing a defense against skin cancer, focus
was placed on developing a method of stimulating natural
melanogenesis, or the natural production of melanin in the skin,
without direct exposure to the potentially harmful ultraviolet
radiation in sunlight.
Initially, University of Arizona researchers attempted to directly
administer the naturally occurring hormone alpha-MSH in order to
elicit this desired result. Although this strategy exhibited
promising results, it was determined that the naturally occurring
MSH had a prohibitively short half-life to be of realistic use as a
therapeutic remedy. However, the positive results gleaned from MSH
administration encouraged further research into the development of Melanotan 1 and Melanotan 2, which exhibit similar effects whilst possessing an extended
half-life for functional therapeutic utilization.
Melanotan 2 Studies and Further Information
Melanotan and Melanotan 2 are both analogs of the peptide hormone
alpha-melanocyte stimulating hormone (α-MSH) that tend to induce
skin tanning. Unlike Melanotan 1, Melanotan 2 has been shown to have aphrodisiac properties, the
additional effect of increasing libido. Melanotan 2 is a cyclic
heptapeptide analog of the alpha-melanocyte stimulating hormone
The effects of Melanotan 2 on the diet and food intake of the
laboratory mice have also been investigated. It has been
demonstrated that the central melanocortin (MC) has been activated
by melanotan 2 when fed and induced in the mice. The six-day
treatment of Melanotan 2 has shown that the peptide actually
reduced the body weight and the adipose tissue in the viscera of
the mice and suppressed the caloric intake of the organism. This
has implications in clinical applications of the possible treatment
to reduce carbohydrate or calorie intake especially for the
overweight and the obese.
Furthermore, the same study has also demonstrated that there was a
sustained increase in the available oxygen consumption in obese
animals. Melanotan 2 also helped reduced the level of serum insulin
and the cholesterol levels when compared with the control
Furthermore, it has been suggested that melanotan 2 actually lowers
the level of acetylcholine A caboxylase expression and even
prevented the reduction of carnitine and palmitoltransferase I mRNA
in muscle-type tissues by pair-feeding in the muscles of the obese
rats. Moreover, the Melanotan 2 peptide actually increased the fat
catabolism in the muscles and even improved the cholesterol
metabolism (Li et al. 2004).
α-Melanocyte-Stimulating Hormone Analogues (Melanotan Peptides)
α-Melanocyte-stimulating hormone (α-MSH) is a naturally occurring endogenous melanotan peptide hormone of
the melanocortin family, which is considered to be the most
important of the melanocyte-stimulating hormones when it comes to
stimulating melanogenesis, a process which in mammals is
responsible for hair and skin pigmentation. α-MSH also plays a role
in feeding behavior, energy homeostasis, and sexual activity
(Bremelanotide and Melanotan 2). α-MSH is a nonselective agonist of
melanocortin receptors MC1, MC3, MC4 and MC5.
Melanotan 1 and Melanotan 2 activate the MC1 receptor, which is responsible for effects on
skin pigmentation. Melanotan 2 and PT-141 both stimulate the MC3
and MC4 receptors which are responsible for the regulation of
appetite, metabolism, and sexual behavior. However, PT-141 Bremelanotide does not stimulate the MC1 receptor.
A few synthetic analogues of α-MSH have been investigated for their
apparent photoprotective effects against ultraviolet (UV) radiation
from the sun, namely Melanotan (afamelanotide) and Melanotan 2, referred to as Melanotan 2. Bremelanotide, another analogue of
α-MSH similar to Melanotan 2, is currently under development for
the treatment of sexual dysfunction. All of these melanotan
peptides have significantly greater potencies than α-MSH, but with
distinctive selectivity peptide profiles.
Buy Melanotan, Melanotan 2 and PT-141 Online Supplier
PeptideSciences™, the leading Melanotan 2 supplier, proudly offers a large selection of premium quality α-MSH
analogues that are assayed at a minimum purity of 99%. We
understand the great importance of purchasing only the highest
quality melanotan peptides online to ensure maximum potency
(stability) and purity of your Melanotan 1, Melanotan 2 and PT-141
when you shop online.
Sun Kissed All Year Round
Don't be surprised. A lot of people haven't heard of Melanotan.
Melanotan is a tanning peptide that stimulates the production of
melanin in the body to foster a deep, natural tan. This is the
body's way of protecting itself from too much sun exposure by
increasing the level of melanin in the body. Melanin is your body's
natural response to UV damage. The end result is a darkening of the
Obviously the drawback from too much tanning is the amount of
damage UV radiation can do. This can lead to skin cancer and other
serious health problems.
How it works?
Melanotan 2 works by stimulating the release of the pigment melanin
from the skin. Less UV exposure is necessary with Melanotan 2
compared to “normal tanning”, and the tan that occurs with tanning
injections is deeper and longer lasting than an individual’s
“normal tan”. Melanotan works best (has the most noticeable
effects) on people with fair skin tones.
How is MT2 Used?
Peptide is shipped enclosed in a vial. It is in a powder dried form
that must be reconstituted using sterile water and then injected
under the skin (subcutaneously) where it is is absorbed into the
skin and spread throughout.
Lasting Tan: Even if dosage is stopped, a warm sun-kissed tan can last for
months at a time without any exposure to the sun. Conversely, tans
developed naturally fade in around a months time.
Flexibility of Use: Able to take a small loading dose with continued dosing until
desired skin pigmentation is achieved. Once achieved only need to
dose once every couple of weeks to maintain same pigment.
Reduced exposure to sunlight (UV rays): Melanotan still needs exposure to sunlight to be effective.
However it will allow the user a significant reduction in time to
develop desired tan .
Side effects: Side effects for Melanotan 2 include nausea, appetite loss,
facial flushing and increased libido. Side effects are generally
mild and tend to diminish over time. Some research suggests nausea
can be reduced by injecting MT-II after dinner or before bed.
Athletes and bodybuilders have injected peptides like Melanotan 2
intermittently to prolong their tan since a tan aided by Melanotan
can last 2-3 times as long as a normal tan. Like other peptides,
Melanotan is a fragile molecule, therefore melanotan nasal sprays,
pre-mixed peptides, pills, oral and loose powder are not often
legitimate for research effectiveness.
Dosage: Research quality peptides are supplied as a lyophilized powder
that must be mixed with bacteriostatic water for injection just
prior to use. A suggested research dose is weight based. Below
example is for average 70kg adult
Based on this, 100kg male can take 1.5-2mg as a weekly dosage. 50kg
female should start off with 0.25mg to be safe and then move to
0.5mg and 1mg if needed.
Pre-loading does is 2x or 3x smaller than your normal maintenance
dosage. As a reminder you do not need to do this unless you are in
a rush to get really dark in a matter of days.
Noteworthy: Many online sources sell an ineffective product. Also peptides are
fragile by nature, and are not effective when they are taken orally
(pills, shakes, etc) because they will be broken down by the
digestive process. Instead, peptides are mixed with bacteriostatic
water, and then injected under the skin with an insulin needle.
Peptide injections in this manner are nearly painless, and have
clinically proven effectiveness.
Conclusions: Melanotan not a treatment or cure for anything. Nor should it be
considered a preventative treatment to skin cancer. Despite this
tanning peptide being known to protect the skin through the natural
tanning process, it is not in and itself a guaranteed full proof UV
shield. However it is a great way for those who don't tan easily to
get sun-kissed all year long with minimal exposure to the sun.