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HGH Fragment 176-191 Epidermal Growth Factor EGF Growth Hormone Peptide 66004-57-7

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HGH Fragment 176-191 Epidermal Growth Factor EGF Growth Hormone Peptide 66004-57-7

Brand Name : KANGDISEN
Model Number : 2 mg/vial
Certification : GMP
Place of Origin : China
MOQ : negotiatable
Price : negotiatable
Payment Terms : MoneyGram, T/T, Bitcoin
Supply Ability : 100,000 vials each month
Delivery Time : 3 days
Packaging Details : 10 vials/kit
Appearance : lyophilized white powder
Purity : more than 98%
Synonyms : HGH Frag 176-191
Sequence : H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH
vial volume : 2 ml
CAS : 66004-57-7
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HGH Fragment 176-191 Epidermal Growth Factor EGF Growth Hormone Peptide 66004-57-7


HGH Fragment 176-191


GH Fragment is the modified form of amino acids 176-191 of the growth hormone peptide. It is a 15-mer peptide residue of the C-terminus of HGH to which tyrosine is added at the N-terminal end.

The FRAG 176-191 is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces growth hormone (GH) in a specific and physiological manner. To date studies suggest that (HGH fragment 176-191) has several beneficial features: it reduces abdominal fat (in particular visceral fat), without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile. These characteristics make it an ideal candidate for the treatment of excess abdominal fat, an important aspect of HIV-associated lipodystrophy.


SequenceH-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH
One Letter SequenceYLRIVQCRSVEGSCGF
Physical ApperanceWhite Powder
Form & FormulationsSterile Filtered white lyophilized (freeze-dried)
Stability2 months at room temperature 24 months from date of receipt, ­20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, ­20 to ­70 °C under sterile conditions after reconstitution.
Purity>98% by RP-HPLC
StorageLyophilized HGH FRAG 176-191 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C.

Growth Hormone peptide fragment 176-191


Growth Hormone peptide fragment 176-191, also known as HGH Frag 176-191, is a modified form of amino acids 176-191 of the GH polypeptide. Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the Growth Hormone molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural Growth Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormone. Like Growth Hormone, the hgH fragment 176-191 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food materials into body fat) both in laboratory testing and in animals and humans.


Laboratory Tests and Fat Loss
In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the hgH fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), hgH fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted Growth Hormone effect. Research dosages of 500mcg of the hgH fragment 176-191 daily for 30 days did show a reduction of body fat in the mid abdominal area in both obese, over-weight, and average built people.
Fragment 176-191 as an Active HGH Truncated Peptide
hgH fragment 176-191 is an analog of the growth hormone-releasing factor (GRF) which signals the effects of growth hormone. It is a 15-mer peptide residue of the C-terminus of HGH to which tyrosine is added at the N-terminal end. This synthetically produced hormone is very common to weightlifters and bodybuilders because of a number of physical benefits. Studies claimed that it actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body.

These segments of the synthetic peptide hgH 176-191 have been investigated for their in vivo effects in laboratory mice musculus. Research results have shown that hgH 176-191 have resulted to a short-period increase in blood glucose and a more sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191. In addition, the researchers have suggested that functionality of the peptide depends not only in the informational sequence but should also have the correct physical configuration (Ng and Borstein 1978).


Also, this fragment, being a region of high accessibility to proteases and also rich in proline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains. This then suggest that such residue is significant in conformational changes be serving as sites for peripheral protein binding in some body cells (Low et al. 1984).


In another study of Ng et al. (2000) on animal subjects, they found out that a 500mcg dosage of the said hormone increased the lipolytic activity in adipose tissues without having negative influence in the blood glucose level. Furthermore, though it behaves like a human growth hormone (hgH), it does not causes hyperglycemia because it does not compete with hgH receptors (Wu et al. 1993). Because of such effects, researchers have suggested that it might be used for the elimination of excess abdominal fat which is a significant aspect of HIV-associated lipodystrophy.


The (hgH fragment 176-191) exhibits the ability to burn through stubborn adipose tissue, while increasing energy expenditure, muscle mass, and fat oxidation. All studies have pointed to the fact that the fragment is an effective treatment for obesity and fat loss, and much safer than its Human Growth Hormone counterpart.


(Please NOTE: It is normal for FRAGMENT (176-191) to mix cloudy after reconstitution with bacteriostatic water.)


HGH Fragment 176-191 Questions


What is growth hormone?


Synthetic Growth Hormone (Somatropin) is an artificially created hormone (made up of a sequence of 191 amino acids) that is identical to the one found in humans. Some common names of synthetic growth hormone include: Genotropin by Genentech, Humatrope by Eli Lilly, Nutropin by Genentech and Saizen by Serono. While many companies are capable of generating growth hormone not all of the companies are capable of creating the correct structure that is identical to naturally occurring growth hormone.


The structure determines the strength with which the growth hormone molecule binds to a receptor which will in turn affect the “strength” of the events leading to protein transcription, metabolism, IGF-1 creation, etc. It is this inconsistency that accounts in part for the differences in effectiveness of various produced synthetic growth hormone. Synthetic growth hormone is not really true or natural growth hormone. It was manufactured in a laboratory and not by your pituitary.


Naturally produced Growth Hormone is produced in the anterior pituitary. It is made up of a blend of amino acids with the majority of them being the 191 amino acid variety.


How does growth hormone work?


Growth hormone in the body is released in a pulsating fashion. It has been demonstrated that this pattern promotes growth. The pituitary is capable of rather quickly synthesizing very large amounts of growth hormone which it stores in both a finished and unfinished form. Adults rarely experience growth hormone pulses that completely deplete these stores. As we get older we do not lose the ability to create and store large amounts of growth hormone, rather we experience a diminished capacity to instruct their release. The growth hormone pulse is measured in a wave with the trough being the “off” or non-secretion of growth hormone and the crest being the “on” or highest point during growth hormone secretion.


The volume of growth hormone that is released in the body cannot be properly compared to the administration of synthetic growth hormone for the reason that a set of behavioral characteristics associated with natural growth hormone differ from those of synthetic growth hormone.


Therefore attempting to find a natural growth hormone to a synthetic growth hormone equivalency is not very productive because in the end what is probably most important is: The quantity and quality of intracellular signaling events and the degree to which growth hormone stimulates autocrine/paracrine (locally produced/locally used) muscle IGF-1 & post-exercise its splice variant MGF.


What is Human Growth Hormone (HGH) Fragment 176-191?


The HGH Fragment is a modified form of amino acids 176-191 at the C-terminal region of the human growth hormone (HGH). Studies have shown that it works by mimicking the way natural HGH regulates fat metabolism but without the adverse effects on insulin sensitivity (blood sugar) or cell proliferation (muscle growth) that is seen with unmodified HGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis (breaking down of fat) and inhibits lipogenesis (the formation of fatty acids and other lipids in the body).


HGH fragment 176-191 is meant to be 12.5 times stronger than human growth hormone (HGH) for weight loss than standard human growth hormone (HGH).


Of particular note is that in studies HGH fragment 176-191 had the ability to increase IGF-1 levels which translates into the fragments ability to give anti-aging effects.


How much Human Growth Hormone (HGH) Fragment 176-191 should be used?


In most studies favorable results have been shown with dosages between 400-600mcg or 4-6mcg/kg split into multiple dosages per day.


How long should Human Growth Hormone (HGH) Fragment 176-191 be used?


In most studies no adverse side effects were reported with continuous use per the dosage limits in the above answer.


What is a typical protocol for Human Growth Hormone (HGH) Fragment 176-191?


Studies have suggested the following:

A typical beginner protocol would be:

200mcg before breakfast

200mcg 30 minutes prior to training
Approximately 5-7 days a week – subcutaneous injections


A typical intermediate protocol would be:
250mcg before breakfast
250mcg 30 minutes prior to training
Approximately 5-7 days a week – subcutaneous injections


A typical advance protocol would be:
200mcg before breakfast
200mcg before lunch
200mcg 30 minutes prior to training
7 days a week – subcutaneous injections


When dosing multiple times a day at least 3 hours should separate the administrations.


What are some of the possible side effects with Human Growth Hormone (HGH) Fragment 176-191?


Reported side effects have included: hypersomnia (excessive sleeping), insomnia, burning feeling at injection spot (last 10-15 minutes). All side effects went away after 2-3 days of discontinuing use.


Should food be consumed before or after the injection of Human Growth Hormone (HGH) Fragment 176-191?


Studies have shown that administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait at least 30 minutes to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want.



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