Protabolin Mens Enhancement Supplements 3593-85-9 Or-Bolic Probolik
Methandriol dipropionate (brand names Arbolic, Durabolic, Or-Bolic,
Probolik, Protabolin), or methylandrostenediol dipropionate, also
known as 17α-methylandrost-5-ene-3,17-diol 3,17β-dipropionate, is a
synthetic, injected anabolic-androgenic steroid (AAS) and a
17α-alkylated derivative of 5-androstenediol.
It is an androgen ester – specifically, the C3,17β dipropionate
ester of methandriol (17α-methyl-5-androstenediol) – and acts as a
prodrug of methandriol in the body.Methandriol dipropionate is
administered by intramuscular injection and, relative to
methandriol, has an extended duration via this route of several
days due to a depot effect afforded by its ester.It was marketed in
the United States,but is no longer available in this country.
Methylandrostenediol (methandriol for short) is an anabolic steroid derived from
dihydrotestosterone. The drug itself is manufactured in two very
distinct forms. The first is unesterified (straight)
methylandrostenediol, which is used when making an oral medication
with this steroid (although an injectable once existed in the
U.S.). It is also found as esterified methylandrostenediol
dipropionate, which is prepared as an injectable.
The added propionate esters in the injectable form extend the
activity of the drug for several days. Basically, methandriol drugs
are altered c17-alkylated forms of 5-androstenediol. Methandriol is
classified as a weak anabolic with weak androgenic properties. It
also seems to display some level of estrogenic activity, making
this steroid less ideal for dieting. The drug is generally
considered too mild, and is not widely popular among bodybuilders
and athletes. Sometimes, however, it is used in place of other
anabolic/androgenic agents in bulking stacks when available.
Methandriol was first described in 1935, making this a very old
agent as far as synthetic anabolic steroids are concerned.
Methylandrostendiol was developed into a medicine by Organon, which
sold it in the United States under the Stenediol brand name in both
oral (methylandrostenediol) and injectable (methylandrostendiol
Many other generics and other brands of methylandrostenediol soon
followed, and the drug was a popular anabolic agent in the United
States during the 1950’s. Methandriol was essentially the first
steroid perceived to have a notable separation of anabolic (higher)
and androgenic (lower) effect, a persistent goal of pharmaceutical
Early product literature described it as, “a steroid which has
considerable of the male hormone’s tissue-building action without
to the same extent causing virilization.”534 It was indicated for use as a, “tissue-builder in cases of
retarded growth or failure to gain weight accompanied by protein
wastage, negative nitrogen balance, or failure to build body
Early assessments of methandriol being primarily anabolic in nature
did not hold up well with later extensive use in humans. It was
eventually determined that in doses sufficient to promote weight
gain, its anabolic properties were accompanied by significant
Ultimately, this drug would be viewed as one of balanced anabolic
and androgenic action, not as a highly anabolic agent as originally
thought. Organon would go on to develop more effective anabolic
agents, such as their 19-nor series of drugs including Durabolin,
Deca-Durabolin, and Maxibolin, and eventually discontinued the
The other U.S. brand and generic forms of the drug would follow as
well, although methylandrostenediol would persist in the U.S. scene
for some time. Currently, no domestic source of the drug exists,
although it is still found in certain international markets. It
seems most prominent in Australia at the present time, where it
remains included in a number of veterinary anabolic steroid
Methandriol is available in select human and veterinary drug
markets. Composition and dosage may vary by country and
Methylandrostendiol is a modified form of dihydrotestosterone. It
differs by: 1) the addition of a methyl group at carbon 17-alpha to
protect the hormone during oral administration and 2) the
introduction of a double bond between carbons 5 and 6, which seems
to increase the anabolic strength of the steroid (partly by making
it resistant to metabolism by 3-hydroxysteroid dehydrogenase in
skeletal muscle tissue). Methylandrostenediol dipropionate contains
methylandrostenediol modified with the addition of 2 carboxylic
acid esters (propionic acid) at the 3-beta and 17-beta hydroxyl
groups, which delay the release of free methylandrostenediol from
the site of injection (depot).
Side Effects (Estrogenic):
Methandriol is not directly aromatized by the body, although one of
its known metabolites is methyltestosterone, which can aromatize.
Methlyandrostenediol is also believed to have some inherent
estrogenic activity. It is, likewise, considered a weakly to
moderately estrogenic steroid. Gynecomastia is possible during
treatment, but generally only when higher doses are used. Water and
fat retention can also become issues, again depending on dose.
Sensitive individuals may need to addition an anti-estrogen such as
Nolvadex® to minimize related side effects.
Side Effects (Androgenic):
Although often classified as an anabolic steroid,
methylandrostenediol is sufficiently androgenic. Androgenic side
effects are common with this substance. This may include bouts of
oily skin, acne, and body/facial hair growth. Anabolic/androgenic
steroids may also aggravate male pattern hair loss. Women are
warned of the potential virilizing effects of anabolic/androgenic
steroids. These may include a deepening of the voice, menstrual
irregularities, changes in skin texture, facial hair growth, and
clitoral enlargement. Note that methylandrostenediol is not
affected by 5-alpha reductase, so the relative androgenicity of
this steroid is not affected by the concurrent use of finasteride
Side Effects (Hepatotoxicity):
Methandriol is a c17-alpha alkylated compound. This alteration
protects the drug from deactivation by the liver, allowing a very
high percentage of the drug entry into the bloodstream following
oral administration. C17-alpha alkylated anabolic/androgenic
steroids can be hepatotoxic. Prolonged or high exposure may result
in liver damage. In rare instances life-threatening dysfunction may
develop. It is advisable to visit a physician periodically during
each cycle to monitor liver function and overall health. Intake of
c17-alpha alkylated steroids is commonly limited to 6-8 weeks, in
an effort to avoid escalating liver strain. Injectable forms of the
drug may present slightly less strain on the liver by avoiding the
first pass metabolism of oral dosing, although may still present
Side Effects (Cardiovascular):
Anabolic/androgenic steroids can have deleterious effects on serum
cholesterol. This includes a tendency to reduce HDL (good)
cholesterol values and increase LDL (bad) cholesterol values, which
may shift the HDL to LDL balance in a direction that favors greater
risk of arteriosclerosis.
The relative impact of an anabolic/androgenic steroid on serum
lipids is dependant on the dose, route of administration (oral vs.
injectable), type of steroid (aromatizable or non-aromatizable),
and level of resistance to hepatic metabolism. Methylandrostenediol
has a strong effect on the hepatic management of cholesterol due to
its structural resistance to liver breakdown and (with the oral)
route of administration.
Anabolic/androgenic steroids may also adversely affect blood
pressure and triglycerides, reduce endothelial relaxation, and
support left ventricular hypertrophy, all potentially increasing
the risk of cardiovascular disease and myocardial infarction.
To help reduce cardiovascular strain it is advised to maintain an
active cardiovascular exercise program and minimize the intake of
saturated fats, cholesterol, and simple carbohydrates at all times
during active AAS administration. Supplementing with fish oils (4
grams per day) and a natural cholesterol/antioxidant formula such
as Lipid Stabil or a product with comparable ingredients is also
Side Effects (Testosterone Suppression):
All anabolic/androgenic steroids when taken in doses sufficient to
promote muscle gain are expected to suppress endogenous
testosterone production. Without the intervention of
testosterone-stimulating substances, testosterone levels should
return to normal within 1-4 months of drug secession. Note that
prolonged hypogonadotrophic hypogonadism can develop secondary to
steroid abuse, necessitating medical intervention.
Studies have shown that taking an oral anabolic steroid with food
may decrease its bioavailability. This is caused by the fat-soluble
nature of steroid hormones, which can allow some of the drug to
dissolve with undigested dietary fat, reducing its absorption from
the gastrointestinal tract. For maximum utilization, oral forms of
this steroid should be taken on an empty stomach.
Early prescribing guidelines for Stenediol recommend a dosage of 25
mg given 2 to 5 times per week by oral, buccal, or intramuscular
route. For physique- or performance-enhancing purposes, a typical
dosage is in the range of 25-50 mg daily for the oral form, and
200-400 mg per week with the injectable. In order to keep blood
levels more even with the injectable, it is generally administered
once every three to four days.
Cycles generally last for no more than 6 to 8 weeks, in an effort
to minimize hepatotoxicity and strain on the liver and cholesterol
values. This level of use is sufficient for moderate gains in
muscle size and strength, which may be accompanied by a low level
of water retention.
While it may be possible to use methylandrostenediol alone for
muscle-building purposes, it is most often combined with other
anabolics for a stronger effect. Combined with Deca-Durabolin® or
Equipoise®, for example, measurable gains of hard muscle mass,
without an extreme level of water retention, may be noticed.
This is the general composition of most Australian vet blends that
include methylandrostenediol. When looking for a more pronounced
gain in mass, a stronger androgen such as testosterone may be
added. The resulting growth can be quite exceptional, but the user
will also have to deal with a much stronger set of estrogenic side
effects. The drug sometimes also combines well with non-aromatizing
anabolics such as Winstrol®, Primobolan®, or oxandrolone. The
result here should be a more pronounced effect on muscle hardness,
with a moderate gain of solid lean tissue.
Early prescribing guidelines for Stenediol recommend a dosage of 25
mg given 2 to 5 times per week by oral, buccal, or intramuscular
route. Methylandrostenediol is generally not recommended for women
for physique- or performance-enhancing purposes due to its
androgenic nature and tendency to produce virilizing side effects.
Pharmaceutical preparations containing Methandriol remain scarce.
The only place where this steroid is still produced in an volume is
Australia, where a few veterinary preparations include methandriol
in their blends. These products are rarely traded in international
commerce due to tight controls on anabolic steroids in that
Some more information About Methandriol Dipropionate
Methandriol dipropionate, used in some Australian veterinary
products, is to be avoided by male bodybuilders. It is highly
estrogenic, and has no redeeming properties. Methandriol is a poor
anabolic and the mythical “receptor-cleaning” properties that have
been claimed for it are pure fantasy.
An anti-aromatase would not correct the estrogenic problems of
methandriol dipropionate, since it is directly estrogenic, not
requiring conversion by aromatase. An anti-estrogen such as Clomid
would probably help, but since methandriol is a poor anabolic
anyway, there is no point to a methandriol/Clomid stack.
Methandriol is the chemical name of active ingredient in Methastan.
Methastan was a registered trademark of Schering in the United
States and/or other countries.
Methandriol Dipropionate (M.D.) is a form of the water-dissolved
Methandriol but Methandriol Dipropionate remains effective for a
longer period of time. On the one hand, Methandriol Dipropionate
can be dissolved in oil for injection purposes and, on the other
hand, Methandriol Dipropionate is produced in tablet form since it
is also effective when taken orally M.D. has a strong anabolic and
androgenic component so that it is suitable for the buildup of
strength and muscle mass. The effect can be compared to a cross
between Deca-Durabolin and Testosterone enanthate. Like
testosterone it con- tributes to a gain in both strength and muscle
but does not retain more water than Deca-Durabolin.
The best results can be obtained, however, if M.D. is not taken
alone but in combination with an- other steroid. This is because
M.D. is able to magnify the effects of other steroid compounds. It
does this by increasingly sensitizing the androgenic receptors of
the muscle cell, allowing a higher amount of the steroid molecules
of the additionally taken steroids to be absorbed by the receptors.
This also explains why injectable M.D. is only available today as a
combination compound with an additional steroid substance.
Injectable M.D. is only available in the Australian veterinary
steroids Drive, Spectriol, Geldabol, and Filibol Forte so that
procurement of the compound is difficult. The few athletes using
this drug report good strength gains, a solid muscle gain, and low
water retention. The combination steroids aromatize only slightly
so, when taking only M.D., the use of antiestrogens is perhaps
appropriate. The injectable form is only slightly toxic.
The usual dosage for athletes is 100 mg every 2-3 days. In Europe
only the oral form of M.D. is available. Also in this case it is
beneficial to combine M.D. with another steroid, preferably an
injectable one. The normal daily dose is 40-60 mg and is usually
taken in 2-3 individual doses spread over & day The tablets are
usually taken for only 4-6 weeks since the effect decreases
quickly, thus requiring higher dosages.
They are also I 7-alpha alkylated so even a low dos-age and a short
intake can be damaging to the liver. Because of its androgenic
effect women rarely use M.D. Possible side effects of the tablet
form can be elevated levels of liver toxins, gastrointestinal pain,
acne, gynecomastia, increased aggressiveness, and high blood